MovDisordV3, Main, Exploration, bibRecord, 006611

Levodopa‐induced regional cerebral blood flow changes in normal volunteers and patients with Parkinson's disease

Identifieur interne : 006611 ( Main/Exploration ); précédent : 006610; suivant : 006612

Levodopa‐induced regional cerebral blood flow changes in normal volunteers and patients with Parkinson's disease

Auteurs : J. L. Montastruc [France] ; Celsis [France] ; A. Agniel [France] ; J. F. Demonet [France] ; B. Doyon [France] ; M. Puel [France] ; J. P. Marc-Vergnes [France] ; A. Rascol [France]

Source :

Movement Disorders [ 0885-3185 ] ; 1987.

RBID : ISTEX:0B852AF545985A7F8408834127000AD8559BA1B8

Descripteurs français

Pascal (Inist)
- Antiparkinsonien, Chimiothérapie, Débit sanguin régional, Etude comparative, Homme, Lévodopa, Normal, Parkinson maladie, Système nerveux pathologie.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Administration, Oral, Aged, Antiparkinson agent, Blood flow, Bromocriptine (administration & dosage), Carbidopa (administration & dosage), Cerebrovascular Circulation (drug effects), Chemotherapy, Comparative study, Dopamine, Drug Therapy, Combination, Female, Healthy volunteers, Human, Humans, Levodopa, Levodopa (administration & dosage), Levodopa (adverse effects), Male, Middle Aged, Nervous system diseases, Neuropsychological Tests, Normal, Parkinson Disease (drug therapy), Parkinson Disease (psychology), Parkinson disease, Parkinson's disease, Regional Blood Flow (drug effects), Regional blood flow, Single photon emission computed tomography, Tomography, Emission-Computed.
MESH :
- chemical , administration & dosage : Bromocriptine, Carbidopa, Levodopa.
- chemical , adverse effects : Levodopa.
- drug effects : Cerebrovascular Circulation, Regional Blood Flow.
- drug therapy : Parkinson Disease.
- psychology : Parkinson Disease.
- Administration, Oral, Aged, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Tomography, Emission-Computed.

Abstract

Single photon emission computed tomography was used to measure regional cerebral blood flow in six normal subjects and 12 patients with Parkinson's disease, before and after acute oral administration of levodopa. The drug induced a significant increase in cerebral blood flow both in controls and patients. Before levodopa, there was no significant difference between the groups, either in flow values or in their pattern. The clinical effects of levodopa were not related to the hemodynamic changes. The results suggest that measuring the flow response to levodopa is not appropriate to demonstrate variations in central dopaminergic receptor sensitivity in man.

Url:

https://api.istex.fr/document/0B852AF545985A7F8408834127000AD8559BA1B8/fulltext/pdf

DOI: 10.1002/mds.870020405

Affiliations:

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<term>Bromocriptine (administration & dosage)</term>
<term>Carbidopa (administration & dosage)</term>
<term>Cerebrovascular Circulation (drug effects)</term>
<term>Chemotherapy</term>
<term>Comparative study</term>
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<term>Drug Therapy, Combination</term>
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<term>Healthy volunteers</term>
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<term>Levodopa (administration & dosage)</term>
<term>Levodopa (adverse effects)</term>
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<term>Middle Aged</term>
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<term>Normal</term>
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<term>Parkinson Disease (psychology)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
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<term>Regional blood flow</term>
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<front><div type="abstract" xml:lang="en">Single photon emission computed tomography was used to measure regional cerebral blood flow in six normal subjects and 12 patients with Parkinson's disease, before and after acute oral administration of levodopa. The drug induced a significant increase in cerebral blood flow both in controls and patients. Before levodopa, there was no significant difference between the groups, either in flow values or in their pattern. The clinical effects of levodopa were not related to the hemodynamic changes. The results suggest that measuring the flow response to levodopa is not appropriate to demonstrate variations in central dopaminergic receptor sensitivity in man.</div>
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Movement Disorders (revue)

Levodopa‐induced regional cerebral blood flow changes in normal volunteers and patients with Parkinson's disease

Levodopa‐induced regional cerebral blood flow changes in normal volunteers and patients with Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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